12月27日，哈佛大学博士后严无名博士应邀来公司交流访问，并作题为《Methodology Development and Complex Molecule Synthesis》的学术报告。
严博士的报告从点击化学合成三氮唑开始，介绍了多种合成三氮唑的方法，并着重介绍三氮唑与金属配位后，用来催化偶联反应的研究。报告第二部分重点报告了他在哈佛大学博士后期间从事天然产物Halaven的全合成的工作，并对合成中关键步骤进行了仔细的讲解，通过多种途径来证实自己的合成方法，把合成中的产生的副产物通过一定的手段变副为宝。报告会上，严博士以其渊博的学识，深入浅出地回答了多位师生提出的问题，带领大家领略了有机合成的魅力，感受到有机合成在药物合成中的重要性，给与会老师和学生颇多启示。
严无名博士
美国百健公司 225 Broadway, Cambridge, MA 02142, US
Email:ynwuming@gmail.com
基本信息
现于美国百健（Biogen）从事低核苷酸液相合成研究工作
教育背景
l2008.1-2012.4，博士，美国西弗吉尼亚大学，有机化学
l2002.9-2006.6，本科，北京化工大学，应用化学
科研工作经历
Ø2012.5-2015.5，博士后，哈佛大学化学与化学生物系 Yoshito Kishi教授实验室
· 通过选择性NHK偶合反应完成对天然产物软海绵素B（Halichondrin B）的C1-C19片段高效合成
· 发明酸碱离子交换树脂系统完成软海绵素中多醚核心结构合成
Ø2008.1-2012.4，博士研究生，西弗吉尼亚大学化学系史晓东教授实验室
· 成功完成1，2，3-三唑多种功能化的方法学研究
· 证实1，2，3-三唑作为配体在金属催化的应用
· 发现1，2，3-三唑的荧光光学性质以及应用
· 合成以1，2，3-三唑为linker的金属有机结构材料（MOF）以及性能测试
研究论文
1."Chromium-Mediated Coupling and Application to the Synthesis of Halichondrins" Kishi, Y.Yan, W .; Li. J.; Li, Z.2015, US 62/155,067; H0824.70192US00.
2."Selective Activation/Coupling of Poly-halogena ted Nucleophiles in Ni/Cr-Mediated Reactions: Sy nthesis of C1-C19 Building Block of Halichondrin B s"Yan, W.; Li. Z.; Kishi, Y.J. Am. Chem. Soc.201 5, 137,6219.
3."Unified Synthesis of C1-C19 Building Blocks of Halichondrins via Selective Activation/Coupling of Poly-halogenated Nucleophiles in (Ni)/Cr-Mediated Reactions" Li. J.;Yan, W.; Kishi, Y.J. Am. Chem. Soc.2015,137,6226.
4."Synthesis and characterization of N-2-aryl-1, 2, 3-triazole based iridium complexes as photocatalysts with tunable photoredox potential" Cai, R.;Yan, W.; Bologna, M.; Silva, K.; Ma, Z.; Finklea, H.; Petersen, J. L.; Li, M.; Shi, X.Org. Chem. Front.2015,2,141 (invited contribution).
5."Facile synthesis of fluorescent active triazapentalenes through gold-catalyzed triazole–alkyne cyclization" Cai, R.; Wang, D.; Chen, Y.;Yan, W.; Petersen, J. L.; Shi, X.Chem. Commun.2014, 7303.
6."Secondary Amines as Lewis Bases in Nitroalkene Activation"Yan, W.; Shi, X.; Zhong, C.Asian. J. Org. Chem.2013,2,904.
7."A Pillared Metal-Organic Framework Incorporated with 1,2,3-Triazole Moieties Exhibiting Remarkable Enhancement of CO2Uptake" Gao, W.;Yan, W.; Cai, R.; Williams, K.; Salas, A.; Wojtas, L.; Shi, X.; Ma, S.Chem. Commun.2012, 48, 8898.
8."1,2,3-Triazole: Unique Ligand in Promoting Iron-Catalyzed Propargyl Alcohol Dehydration"Yan, W.; Ye, X.; Akhmedov, N. G.; Petersen, J. L.; Shi, X.Org. Lett.2012,14,2358.
9."Porous Double-Walled Metal Triazolate Framework Based upon a Bifunctional Ligand and a Pentanuclear Zinc Cluster Exhibiting Selective CO2Uptake" Gao, W.;Yan, W.; Cai, R.; Meng, L.; Salas, A.; Wang, X.; Wojtas, L.; Shi, X.; Ma, S.Inorg. Chem.2012,51, 4423.
10."Synthesis of Allene Triazole through Iron Catalyzed Regioselective Addition to Propargyl Alcohols"Yan, W.; Ye, X.; Weise, K.; Petersen, J. L.; Shi, X.Chem. Commun.2012, 48, 3521.
11."Mitsunobu Reaction of the 1,2,3-NH-Triazoles: A Regio- and Stereo-Selective Approach in Reaching Functional Triazole Derivatives"Yan, W.; Liao, T.; Tuguldur, O.; Zhong, C.; Petersen, J. L.; Shi, X.Chem. Asian. J.2011,6,2720.
12."N-2-Aryl-1,2,3-Triazoles: A New Class of UV-Blue Emitting Fluorophores through Planar-Intramolecular-Charge-Transfer"Yan, W.; Wang, Q.; Lin, Q.; Li, M., Petersen, J. L.; Shi, X.Chem. Eur. J.2011,17, 5011.
13."Iron Catalyzed C-O Bond Activation for the Synthesis of Propargyl-1,2,3-Triazoles and 1,1-Bis-Triazoles"Yan, W.; Wang, Q.; Chen, Y.; Petersen, J. L.; Shi, X.Org. Lett.2010,12,3308.
14."1,2,3-Triazole as Special “X-Factor” in Promoting Hashmi Phenol Synthesis" Chen, Y.;Yan, W.; Akhmedov, N.; Shi, X.Org. Lett.2010,12,344.
15."Highly efficient synthesis of vinyl substituted triazoles by Au(I) catalyzed alkyne activation" Duan, H.;Yan, W.; Sengupta, S.; Shi, X.Bioorg. Med. Chem. Lett.2009,3899.
16."Total Synthesis of (+)-Largazole, a Histone Deacetylase Inhibitor"Yan, W.; O’Doherty, G. A.ChemTracts-Organic Chemistry,2009,22, 50.
17."Total Synthesis of (–)-Cephalotaxine" Niu, D.;Yan, W.; Sharif, E.; Rajaratnam, M.; O’Doherty, G. A.ChemTracts-Organic Chemistry,2009,22, 89.
18."Efficient Synthesis of N-2-Aryl-1,2,3-Triazole Fluorophores via Post-Triazole Arylation" Liu, Y.;Yan, W.; Chen, Y.; Petersen, J. L.; Shi, X.Org. Lett.2008,10, 5389.
图为严无名博士在公司讲学
图为院老师学生聆听讲座
